supercoiling

supercoiling
In circular DNA or closed loops of DNA, twisting of the DNA about its own axis changes the number of turns of the double helix. If twisting is in the opposite direction to the turns of the double helix, ie. anticlockwise, the DNA strands will either have to unwind or the whole structure will twist or supercoil - termed negative supercoiling. If twisting is in the same direction as the helix, clockwise, which winds the DNA up more tightly, positive supercoiling is generated. DNA that shows no supercoiling is said to be relaxed. Supercoiling in circular DNA can be detected by electrophoresis because supercoiled DNA migrates faster than relaxed DNA. Circular DNA is commonly negatively supercoiled and the DNA of eukaryotes largely exists as supercoils associated with protein in the nucleosome. The degree of supercoiling can be altered by topoisomerases.

Dictionary of molecular biology. 2004.

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Look at other dictionaries:

  • Supercoiling — eines ringförmigen DNA Moleküls Supercoiled Struktur eines linearen DNA Moleküls …   Deutsch Wikipedia

  • supercoiling — noun The coiling of the DNA helix upon itself; can cause disruption to transcription and lead to cell death …   Wiktionary

  • supercoiling — SYN: superhelicity …   Medical dictionary

  • Supercoiling — Super|coi|ling [...ke̲u̲...; ↑super... u. ↑Coiling] s; s, s: durch bestimmte Enzyme (z. B. ↑Gyrase) bewirkte Überverdrillung der ↑Desoxyribonukleinsäure (wodurch sich Bakterien natürlich vermehren können) …   Das Wörterbuch medizinischer Fachausdrücke

  • Supercoiling — Su|per|coi|ling [...kɔy...] das; s, s <zu ↑super..., engl. to coil »aufwickeln« u. ↑...ing> durch bestimmte ↑Enzyme bewirkte Überverdrillung der ↑Desoxyribonukleinsäure (Med.) …   Das große Fremdwörterbuch

  • Supercoil — Supercoiling eines ringförmigen DNA Moleküls Supercoiled Struktur eines linearen DNA Moleküls …   Deutsch Wikipedia

  • Superhelikal — Supercoiling eines ringförmigen DNA Moleküls Supercoiled Struktur eines linearen DNA Moleküls …   Deutsch Wikipedia

  • Superhelikale DNA — Supercoiling eines ringförmigen DNA Moleküls Supercoiled Struktur eines linearen DNA Moleküls …   Deutsch Wikipedia

  • Supercoiled DNA — Supercoiling eines ringförmigen DNA Moleküls Su …   Deutsch Wikipedia

  • DNA supercoil — Supercoiled structure of circular DNA molecules with low writhe. Note that the helical nature of the DNA duplex is omitted for clarity …   Wikipedia

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